Characterization of Biological Structures with Nonlinear Chemical Imaging Nanomicroscopy

نویسندگان

  • Richard D. Schaller
  • Justin C. Johnson
  • Kevin R. Wilson
  • Lynn F. Lee
  • Louis H. Haber
  • Richard J. Saykally
چکیده

Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

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تاریخ انتشار 2003